Renoprotective Properties of Angiotensin Receptor Blockers beyond Blood Pressure Lowering

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Renoprotective properties of angiotensin receptor blockers beyond blood pressure lowering.

Clinical studies have demonstrated that some antihypertensive agents provide renoprotection independent of BP lowering. Recent in vitro and in vivo studies evaluated the mechanisms involved in this protection. First, the in vitro effects of several angiotensin II type 1 receptor blockers (ARB), calcium channel blockers (CCB), and beta blockers (BB) on various mediators were compared: Formation ...

متن کامل

Angiotensin receptor blockers: more than just blood pressure lowering drugs?

H ypertensive patients have an excess of other cardiovascular risk factors, including hyperlipidaemia. Because various antihypertensive drugs, especially diuretics and beta blockers, adversely affect lipid metabolism, these drugs may increase associated risks for coronary artery disease and thus offset some of the beneficial effects of blood pressure reduction. The renin angiotensin system is a...

متن کامل

Vascular protective effects of Angiotensin Receptor Blockers: Beyond Blood pressure.

Angiotensin-II (Ang-II) activates two major types of receptors, angiotensin II type one (AT1R) and type two (AT2R) receptors. While AT1R is widely expressed and mediates most inflammatory Ang-II effects, AT2R, is less expressed and has opposite effects, promoting vasodilation and anti-inflammatory effects . Physiologically, AT2R actions are usually masked by the more abundant AT1R. It has been ...

متن کامل

Targeting effective blood pressure control with angiotensin receptor blockers

Angiotensin receptor blockers (ARBs) have become established as a major class of antihypertensive on the basis of their powerful effects on blood pressure (BP), excellent tolerability and pleiotropic end-organ-protective effects. However, individual ARBs vary in antihypertensive efficacy, which may be important to clinical outcome. Several strategies are available to ensure that BP reductions w...

متن کامل

Angiotensin Receptor Blocker for Stroke Prevention in Atrial Fibrillation: beyond Blood Pressure Lowering?

The renin-angiotensin system (RAS) plays an important role in the development of various cardiovascular diseases, including atrial fibrillation (AF). The arrhythmogenic effects of angiotensin II are associated with atrial fibrosis and hypertrophy, uncoupling of gap junctions, impaired calcium regulation, alteration of various ion channels, and activation of mediators of oxidative stress and inf...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of the American Society of Nephrology

سال: 2005

ISSN: 1046-6673,1533-3450

DOI: 10.1681/asn.2005050522